Abstract
Introduction: laryngeal amyloidosis is an uncommon localized form of amyloidosis. The clinical symptomatology is not specific, and the diagnosis should be evoked in a persistent dysphonia.Case report: A 45-year-old patient who had consulted for dysphonia lasting for 2 years. The nasofibroscopy showed an infiltrative lesion of the vocal cords. The laryngeal biopsy was performed and revealed laryngeal amyloidosis. Search for other locations was negative.Conclusion: dysphonia is the most common symptom of laryngeal amyloidosis. Monitoring is extended because of the risk of recurrence and systemic dissemination.
Highlights
The Amyloidosis are a heterogeneous group of diseases related to an extracellular deposit of proteins capable of adopting a fibrillar abnormal conformation
We report an original case of laryngeal Amyloidosis revealed by dysphonia, and we will analyze the literature to assess clinical, therapeutic and evolving this disease features
A direct laryngoscopy done under general anesthesia has revealed an inflammatory infiltration with edema of the two vocal cords
Summary
The Amyloidosis are a heterogeneous group of diseases related to an extracellular deposit of proteins capable of adopting a fibrillar abnormal conformation. They can be hereditary or acquired, localized or disseminated, asymptomatic or instead of formidable prognosis. We report an original case of laryngeal Amyloidosis revealed by dysphonia, and we will analyze the literature to assess clinical, therapeutic and evolving this disease features. The nasofibroscopy revealed an infiltration with edema of the two vocal cords with reduced mobility [figure 1]. A direct laryngoscopy done under general anesthesia has revealed an inflammatory infiltration with edema of the two vocal cords. Follow-up was marked by stabilization of dysphonia without dyspnea or dysphagia, and without systemic conversion of the disease
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