Larvicidal activity of hydroalcoholic extracts of Persea americana Mill. Seeds against Aedes aegypti

Ana Paula Muniz Serejo,Thaylanna Pinto De Lima,Helene Do Carmo Castro Lacerda,Ana Patrícia Matos Pereira,Denise Fernandes Coutinho,Gustavo Oliveira Everton,João Pedro Mesquita Oliveira,Maria Giulia Alves Carneiro Felizardo

doi:10.33448/rsd-v10i10.18144

Ana Paula Muniz Serejo, Thaylanna Pinto De Lima + Show 6 more

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https://doi.org/10.33448/rsd-v10i10.18144

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Abstract

This study aimed to evaluate the phytochemical composition of hydroalcoholic extracts from the seeds of Persea americana (avocado) and evaluate the larvicidal activity against Aedes aegypti. The extracts were obtained by maceration in a 70% PA ethanol extractant solvent in 1:4/1:6/1:8 hydromodules (7 days), with subsequent concentration in a rotaevaporator. The larvicidal activity was performed by the method recommended by the WHO Lethal Concentration 50% against Aedes aegypti larvae with statistics by the Probit method. Toxicity to non-target organisms was verified by the Artemia salina test. Activity was observed against Aedes aegypti larvae with LC50 ranging from 181.72-401.96 mg L-1 with a 95% confidence interval. Finally, it states that the extract of P. americana has potential for larvicidal activity and does not present toxicity to target organisms, showing itself to be a sustainable alternative for the control and combat of Aedes aegypti larvae.

Highlights

The Aedes mosquito is a vector that transmits arboviruses, has a wide geographic distribution and its expansion is influenced by several factors, including: its behavior, the large size of the urban population, the precariousness of the good proportion of households in relation to the water supply, inadequate disposal of waste, the increase in the number of nonbiodegradable containers and inadequate disposal of solid waste
In the absence of dengue drugs and the variable safety and efficacy of the dengue vaccine, Dengvaxia (Thomas&Yoon., 2019), vector control remains the mainstay of Dengue control programs (Chang et al, 2011)
Several plants have been used by humanity on all continents to control different diseases and pests, in addition to representing an important source of biologically active natural products, many of which constitute a model for the synthesis of a large number of drugs (Simões et al 2017)

Summary

Introduction

The Aedes mosquito is a vector that transmits arboviruses, has a wide geographic distribution and its expansion is influenced by several factors, including: its behavior, the large size of the urban population, the precariousness of the good proportion of households in relation to the water supply, inadequate disposal of waste, the increase in the number of nonbiodegradable containers and inadequate disposal of solid waste. The re-emergence of these diseases caused by arboviruses and transmitted by mosquitoes is observed, with emphasis on Dengue, Chikungunya Fever, Yellow Fever and Zika Fever in several countries in the Americas and in other tropical regions. The entry of these viruses in Brazil, a country already endemic for Dengue, represents a major challenge for public health, as they are all susceptible to infections and there are still no specific antivirals, nor vaccines for prevention free from side effects (Viana et al, 2018 ). Several plants have been used by humanity on all continents to control different diseases and pests, in addition to representing an important source of biologically active natural products, many of which constitute a model for the synthesis of a large number of drugs (Simões et al 2017)

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