Abstract
Prevention of type 1 diabetes mellitus (T1DM) requires early intervention in the autoimmune process directed against β cells of the pancreatic islets of Langerhans, which results from a disorder of immunoregulation, inflammation, and consequently β-cell death. In addition to the autoimmune event, recent evidences have highlighted that l-arginine availability in the pancreatic islet milieu is determinant for the β-cell life and death decision. Furthermore, l-arginine supplementation in diagnosed T1DM patients has shown several benefits, particularly to the vascular complications, the principal cause of death and disability among diabetic people. In this chapter, we discuss the latest studies on l-arginine metabolism, availability, and supplementation in T1DM subjects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
