Abstract
To determine the relationship between lead follicle size and the rate of euploid embryos. Retrospective Cohort Analysis. 284 patients underwent 371 trophectoderm biopsy cycles from 10/2010-3/2013 where the average of the 2 lead follicles on the day of trigger was recorded followed by trophectoderm biopsy and array comparative genomic hybridization to determine ploidy. Cycles were divided into 5 lead follicle size groups based on the average of the 2 lead follicles. Stimulation parameters were compared. Primary outcome measures included % Euploid, # Euploid, # Aneuploid. There was no difference in age, FSH w/in cycle, maximal FSH, total dose, days of stimulation, estradiol (E2) levels on day of hcg, number of immature eggs (M1), GV, or atretic oocytes between the 5 groups. There was no difference in the number of aneuploid blastocysts or percent euploid but there was decrease in the number of euploid embryos with increasing follicle size. A subset analysis demonstrated that there was no relationship between number of M1 and euploidy.Tabled 1<18mm (n= 36)18-18.9mm (n=83)19.0-19.9mm (n=100)20.0-20.9mm (n=72)>21.0mm (n=80)ANOVA p-valueAge (y)37.937.537.837.838.0NSE2 per oocyte retrieved1601892032042260.01# Oocytes retrieved18.518.515.014.313.50.001# M216.615.513.011.511.10.0001# M12.41.41.11.31.0NS# 2pn-zygotes13.011.810.19.38.50.001#Blastocyst for biopsy6.36.75.25.24.30.04% Euploid embryos34%35%32%31%32%NS# Aneuploid embryos3.43.83.43.32.8NS# Euploid embryos2.82.91.81.91.50.006 Open table in a new tab Allowing patients’ follicles to grow larger was associated with higher E2 per oocyte retrieved but was also associated with a decreased number of oocytes, #fertilized and #biopsied. Concomitantly, the number of euploid embryos declined. We recommend caution in pushing patients to larger sizes to recruit more follicles since larger follicles were associated with fewer embryos for biopsy and a lower total number of euploid embryos.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
