Large-for-gestational age is male-gender dependent in artificial frozen embryo transfers cycles: a cohort study of 1295 singleton live births.

Abstract

What is the effect of frozen embryo transfer (FET) on infant birth weight outcomes and which variables predic large-for-gestational age (LGA) infants. In a large cohort study, the birth weight of 1295 singleton live births from blastocyst freeze-all-IVF treatments carried out between February 2015 and February 2017 at a single IVF centre were analysed. All embryo transfers were vitrified-warmed blastocyst transfers in artificial FET cycles, with patients having one (n = 864) or two (n = 431) blastocysts transferred. All live births were from ultrasound confirmed single fetal heart pregnancies. The mean gestational age at delivery was 38.2 (±1.7) weeks, with a 1.11 : 1 female to male ratio for infants delivered. The small and large-for-gestational age rates were 5.02 and 13.28%, with 81.7% of infants appropriate for gestational age. In a multiple logistic regression analysis, the independent variables selected in the model to predict having an LGA infant were maternal parity, infant gender and maternal body mass index (BMI). The risk for LGA at term was significantly higher for male infants when adjusting for maternal parity and BMI (2.8 OR 1.805 to 4.450; P < 0.001). The present study showed that fetal growth of artificial cycle FET pregnancies resulted in an 13.28% LGA infant rate that was mostly male gender dependent.