Large‐Scale Synthesis of Mammalian Gonadoliberin without protection of side‐chain functions

Abstract

AbstractA simple, Large‐scale preparation of mammalian gonadoliberin was elaborated using classical solution methods without protecting side‐chain functions. At the final stage, a hexapeptide segment was condensed with the corresponding tetrapeptide and the obtained decapeptide was purified by a single chromatographic procedure on silica gel. The total efficiency of the whole synthesis and the purity of the product amounted to 34% and 98.3%, respectively.