Large scale multi-centre randomized placebo controlled clinical study proves the efficacy of pumpkin seed in symptomatic benign prostatic hyperplasia (BPH) – G.R.A.N.U. study

Abstract

Of all known herbal drugs in the therapy of BPH, pumpkin seed has the longest tradition. The high level of unique delta-7 sterols is discussed as the active principle. This is supported by a former study where prostate tissue of patients taking pumpkin sterols contained much less dihydrotestosterone, compared to the control group [1]. The aim in the treatment of symptomatic BPH is to improve lower urinary tract symptoms (LUTS) and patient's quality of life (QoL) [2]. This study was carried out to confirm the efficacy of pumpkin seed in a design referring to the recommendations of the International Consultation on BPH and WHO criteria. Method: three treatment groups. 1. pumpkin seed extract (2×500mg capsule per day, PROSTA FINK® FORTE), 2. placebo capsule. 3. pumpkin seed (2×5g per day), The pumpkin is a special variety: GRANU FINK® medicinal pumpkin. Treatment period: 12 months. 1431 patients were randomised. A noticeable decrease in the international prostate symptom score (IPSS) by 3 to 4 points was observed after 3 months followed by gradually continuous decrease until month 12. The QoL improved continuously over time with the remarkable improvement by 36% in the pumpkin seed group. Treatment with pumpkin seed results a strong improvement of micturition complaints. Level of IPSS improvement (%) over 12 months is comparable to most prescription medicines in this indication [3]. The symptom relief is accompanied by a clinically significant improvement of Quality-of-Life by 36%. Pumpkin seed is an effective and safe option for the long-term therapy in men with LUTS due to BPH.