Large-scale manufacturing of soluble hemostatic spacer dressing with excellent mechanical and comfortable properties

Abstract

Death from acute hemorrhage is a major life-threatening. Spacer fabrics-based composite dressings have been widely concerned because of their good hemostasis and protection in wound healing, but the poor liquid absorption and compression recovery properties hinder their utilization. Herein, we report a soluble hemostatic spacer dressing based on a braided yarn of PTFE (core yarn)/carboxymethylated viscose (shell yarn) as the skin contact layer, a wrapped yarn of nylon monofilament (core yarn)/Coolmax (shell yarn) as the spacer layer, and UHMWPE yarn as the waterproof layer for wound healing. Among these, carboxymethylated viscose can stop bleeding, while PTFE has low adhesion and ensures the structural integrity of the spacer fabric. Moreover, the nylon monofilament can endow the dressing with excellent comfortability, resilience, and fatigue resistance. Coolmax can absorb blood. The as-prepared spacer dressing shows excellent mechanical, comfortable, and hemostasis properties. F2 had a hemostasis time of 5.15 min, a low coagulation index of 7.96%, a hemolysis rate of 0.98%, and a blood absorption rate of 159.09%. This work presents an integrated molding method to achieve large-scale manufacturing of spacer dressing, which is expected to guide materials design for future innovations in biomedical applications.