Abstract
Pseudoangiomatous stromal hyperplasia (PASH) is a benign lesion often observed in parts of the mammary stroma in a variety of breast diseases. It is characterized by stromal myofibroblastic proliferation that possesses irregularly anastomosing slit-like pseudovascular spaces lined by a layer of spindle cells. PASH commonly occurs in premenopausal women; however, it has also been observed in men with gynecomastia. Although tumor-forming lesions are rare, we report on a case with a large PASH in a male breast complicated with gynecomastia. Imaging showed a tumor with a diameter of >10 cm in the left breast, and aspiration cytology revealed a benign lesion. Since the tumor was large and gradually increased in size, a simple mastectomy was performed. The tumorous lesion was diagnosed as PASH based on the pathological and immunohistological findings. It was complicated by gynecomastia with acinar and lobular formation, which resembled female mammary gland secretory activity that is observed during lactation.
Highlights
Pseudoangiomatous stromal hyperplasia (PASH) is a lesion often observed in parts of the mammary stroma in a variety of breast diseases
We report on a large PASH in a male complicated with gynecomastia and lobulation that presented with secretory changes resembling lactation
We believe that a complex interaction of numerous hormones developed the pathology for PASH complicated with gynecomastia and lactation period-like changes
Summary
Pseudoangiomatous stromal hyperplasia (PASH) is a lesion often observed in parts of the mammary stroma in a variety of breast diseases It is a benign lesion formed by a stromal myofibroblastic proliferation, possessing irregularly anastomosing slit-like pseudovascular spaces lined by a layer of spindle cells (Lakhani et al 2012). It is sometimes observed as an incidental finding, tumor-forming lesions are rare. The stroma was dense and contained a pseudoangiomatous structure with irregularly anastomosing slit-like spaces These slitlike spaces were lined by spindle-shaped cells, which presented with mild nuclear hypertrophy, but there was no nuclear division or atypia (Figure 4a, b).
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
