Abstract
To the Editor: The histologic appearance of Merkel cell polyomavirus (MCPyV)-positive Merkel cell carcinoma (MCC) has been reported to be distinctive: more uniform, round nuclei and less cytoplasm than cells in MCPyV-negative tumors.1,2 In most of these studies, however, the described morphologic differences were identified by light microscopy, and morphometric analysis was done on a limited number of cases.1,3 Extraction of nuclear features by computational methods from high-resolution whole-slide digital scans of histologic slides has been shown to improve accuracy and consistency.
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