Abstract
In diabetic hypercholesterolemic rabbits at plasma triglyceride concentrations of approximately 5000 mg/dl, 55% of plasma cholesterol (1400 mg/dl) was in lipoproteins with diameters larger than 75 nm (Sf greater than 400), 40% in smaller very low density and intermediate density lipoproteins, 4% in low density lipoproteins, and 1% in high density lipoproteins. Specific intimal clearance (nl/h.mg aortic cholesterol) of the giant Sf greater than 400 lipoproteins was about 4% of that of the low density lipoproteins. The data suggest that even very low density lipoproteins with diameters smaller than 75 nm were practically excluded from entering the arterial wall. Specific intimal clearance of low density lipoproteins in hypertriglyceridemic, diabetic cholesterol-fed rabbits was similar to that in normal cholesterol-fed rabbits, but low density lipoprotein concentrations in diabetic rabbits were low. Thus, at plasma triglyceride concentrations of approximately 5000 mg/dl, only 5% of plasma cholesterol may be readily available for infiltration of arteries. These results add further support to the hypothesis that hypertriglyceridemic, diabetic cholesterol-fed rabbits are protected against atherogenesis because the major part of plasma cholesterol is carried in large lipoproteins to which the artery is not very permeable.
Highlights
) of the giant S,>400 lipoproteins was about 4% of that of the low density lipoproteins
As an explanation for the retarded development of atherosclerosis in these rabbits, it has been hypothesized that the large lipoproteins are not able to cross the arterial endothelium and that only little cholesterol will enter into the arterial wall [7]
- tion that the permeability coefficient or intimal clearance of total plasma cholesteryl ester in arteries of severely hypertriglyceridemicdiabeticcholesterol-fed rabbits was reduced 50-90% compared to that in normotriglyceridemic cholesterol-fed rabbits with similar aortic cholesterol content [8].it is not known whether this relatively low aortic intimal clearance of cholesteryl ester is due to the largest lipoproteins being excluded from entering arterial tissue or to reduced arterial permeability to all plasma lipoproteins, i.e., that both the large Sf>400 lipoproteins and the smaller very low density, intermediate density, low density, and high density lipoproteins are partly excluded from entering arteries
Summary
) of the giant S,>400 lipoproteins was about 4% of that of the low density lipoproteins. - tion that the permeability coefficient or intimal clearance (nYcm* h) of total plasma cholesteryl ester in arteries of severely hypertriglyceridemicdiabeticcholesterol-fed rabbits was reduced 50-90% compared to that in normotriglyceridemic cholesterol-fed rabbits with similar aortic cholesterol content [8].it is not known whether this relatively low aortic intimal clearance of cholesteryl ester is due to the largest lipoproteins being excluded from entering arterial tissue or to reduced arterial permeability to all plasma lipoproteins, i.e., that both the large Sf>400 lipoproteins and the smaller very low density, intermediate density, low density, and high density lipoproteins are partly excluded from entering arteries. In the present study we measured arterial uptakes of both large and smaller lipoproteins in hypertriglyceridemic diabetic cholesterol-fed rabbits and compared it to uptakes in normal cholesterol-fed rabbits
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