Abstract
We present a novel spectral domain polarization sensitive OCT system (PS-OCT) that operates at an A-scan rate of 70 kHz and supports scan angles of up to 40° × 40°. The high-speed imaging allows the acquisition of up to 1024 × 250 A-scans per 3D scan, which, together with the large field of view, considerably increases the informative value of the images. To demonstrate the excellent performance of the new PS-OCT system, we imaged several healthy volunteers and patients with various diseases such as glaucoma, AMD, Stargardt’s disease, and albinism. The results are compared with clinically established methods such as scanning laser polarimetry and autofluorescence.
Highlights
Since its first introduction in the 1990s [1] OCT has developed into a powerful noninvasive imaging technique that provides high resolution, cross sectional images of translucent tissues [2,3]
The retinal layers can be categorized into polarization preserving layers, birefringent layers (e.g. retinal nerve fiber layer (RNFL) or Henle’s fiber layer) [8,9,10,11] and depolarizing layers (e.g. retinal pigment epithelium (RPE)) [10,12]
The new polarization sensitive OCT (PS-OCT) system is capable of providing specific information on the RPE layer as autofluorescence imaging
Summary
Since its first introduction in the 1990s [1] OCT has developed into a powerful noninvasive imaging technique that provides high resolution, cross sectional images of translucent tissues [2,3]. In the meantime OCT has found a variety of applications in different fields such as neurology, dermatology, gastro-intestinal imaging and cardiology. It still has its main application in the field of ophthalmology [4]. PS-OCT enables the differentiation of several layers within the retina due to the different light-tissue interaction mechanisms. PS-OCT is capable to distinguish these layers, which is important for segmentation, but it can retrieve quantitative information about different structures within the retina
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