Abstract
A localized and release controlled carrier is essential to enhance the effectiveness of bone morphogenetic protein (BMP) on bone regeneration and repair. In this work, TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> nanotube will be used for BMP delivery. Different types of TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> nanotubes were successfully fabricated by changing organic electrolyte composition. Large diameter TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> nanotubes were fabricated at high applied potential (550nm at 90V, 680nm at 100V) by use electrolyte for the second time with new substrate. Furthermore, using CNT as template crystallized TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> nanotubes with 300-500nm diameter could also be got with Ti deposition followed by a high temperature annealing. The fabricated large diameter TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> nanotube could be used for protein delivery testing in the future.
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