Abstract
Defocus scanning, which causes a serious deterioration of the transverse resolution out of the focal zone, is a big obstacle to the application of optical-resolution photoacoustic (PA) endoscopy (OR-PAE) in imaging internal hollow organs. However, the current solution to generate an adjustable focal length is inapplicable for in vivo imaging due to the greatly increased scanning time. In this study, by applying an elongated focus lens that produces Bessel beams to the OR-PAE, we developed a large-depth-of-field optical-resolution PA endoscope with a depth of focus of ∼8.6 mm in air, which can image targets at different depths without axial scanning, while maintaining a relatively constant transverse resolution. Ex vivo experimental results demonstrate the advantage of the endoscope to image biological tissues at different depths. Furthermore, an in vivo experiment presents three-dimensional vascular networks in the rabbit rectum, suggesting the potential of the endoscope for colorectal clinical applications.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.