Abstract
With tangent angle perturbation approach the axial symmetry deformation of a spherical vesicle in large under the pressure changes is studied by the elasticity theory of Helfrich spontaneous curvature model. Three main results in axial symmetry shape: biconcave shape, peanut shape, and one type of myelin are obtained. These axial symmetry morphology deformations are in agreement with those observed in lipsome experiments by dark-field light microscopy and in the red blood cell with two thin filaments (myelin) observed in living state. Furthermore, the biconcave shape and peanut shape can be simulated with the help of a powerful software, Surface Evolver, in which the spontaneous curvature can be easy taken into account.
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