Abstract
Large cell undifferentiated carcinoma of parotid gland is a rare disease of salivary gland cancer accounting about 1%, however, it has high malignancy and very poor prosgnosis. We report a clinical case with symptoms of left parotid gland tumor, rapid growth , invasive skin and superficial ulceration . The differential diagnosis is difficult between parotid adenocarcinoma and skin cancer or metastatic cervical lymphoma. The patient underwent extensive surgical resection of the lesion, radical cervical lymphadenectomy, and reconstruction with local flaps. The definitive diagnosis after surgery: large cell undifferentiated carcinoma of the left parotid gland stage IV (pT4aN0M0). The patient did not receive early radiation therapy, therefore local recurrence and distal metastasis, and death 6 months after surgery.
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