Abstract
Large cell acanthoma: a debate throughout the decades
Highlights
Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma?
Pinkus separated actinic keratosis from large cell acanthoma (LCA) by its tendency towards invasion, and postulated that LCA may be a variant of lentigo senilis or that lentigo senilis may evolve into an LCA [1]
Rabinowitz and Inghirami claimed that LCA was a distinctive keratosis, different from solar lentigo on the basis of the lack of color, absence of elongated hyperpigmented hockey-stick-shaped buds, and presence of hyperploid keratinocytes [4]
Summary
Have we really concluded what a large cell acanthoma is? Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma?. Is it a distinct entity, a solar lentigo, a subtype of seborrheic keratosis, or an HPV-induced acanthoma? A debate in the literature has occurred as to whether LCAs are distinctive lesions or solar lentigos with large nuclei.
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