Abstract
Follicular lymphoma is characterized by the t (14;18)(q32;q21) translocation involving the BCL-2 and IGH genes. Aggressive double-hit lymphomas can arise from follicular lymphoma and are defined by a combination of a chromosomal breakpoint affecting MYC with one or more additional lymphoma associated abnormalities. We present a case of a 66 year-old woman with a history follicular lymphoma who developed a large B-cell lymphoma with a novel Insertional translocation of the entire MYC locus from the 8q24.1 region into the derivative chromosome 14 of the t (14;18) translocation. Additionally, the fusion IGH and BCL2 from the derivative chromosome 14 moved to same chromosome 8 at 8q24.1. To our knowledge, this type of insertion of the entire MYC locus into der (14) of the t (14;18), and subsequent movement of the fused IGH/BCL2 into 8q24.1, has not been previously reported.
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