Large-aperture 256-element fully populated random array for therapeutic ultrasound applications: Experimental study of its functionality and characterization of the radiated field

Abstract

Recently, a new method has been proposed for designing random high-intensity focused ultrasound (HIFU) arrays with the maximum possible filling factor and polygonal elements of equal area, based on capacity constrained tessellation [Rosnitskiy et al., IEEE Trans. UFFC (2018)]. Following this approach, a 256-element piezocomposite array with a radius of curvature of 150 mm, a diameter of 200 mm, and an operating frequency of 1.2 MHz was designed at the Laboratory for Industrial and Medical Ultrasound (LIMU) of Moscow State University. The array was subsequently manufactured by Imasonic (France). It can be driven using a Verasonics ultrasound engine. Electrical matching was performed for each element using matching network created by Image Guided Therapy (France). This report presents the system design procedure and experimental results for array characterization using acoustic holography and acoustic power measurements using the radiation force balance. In addition, a theoretical study was carried out using the “HIFU beam” simulator developed at LIMU (freely available at www.limu.msu.ru) to assess the array's ability to achieve highly nonlinear regimes with shocked pressure waveforms. The possibility of using the array for HIFU applications such as acoustic levitation and manipulation, histotripsy and transcostal HIFU therapy is discussed. [Work supported by RSF 19-12-00148.]