Abstract
In this mini review the status, advantages, and disadvantages of large animal modeling of breast cancer (BC) will be discussed. While most older studies of large animal BC models utilized canine and feline subjects, more recently there has been interest in development of porcine BC models, with some early promising results for modeling human disease. Widely used rodent models of BC were briefly reviewed to give context to the work on the large animal BC models. Availability of large animal BC models could provide additional tools for BC research, including availability of human-sized subjects and BC models with greater biologic relevance.
Highlights
BREAST CANCER BURDENThe annual incidence of breast cancer (BC) in women in the U.S increased from 0.102% in 1980 to a peak of 0.142% in 1999, and decreased slightly, plateauing at ~0.131% from 2011-2017 [1]
Large Animal Breast Cancer Models and [2] triple-negative BC (TNBC) should allow development and testing of technologies and treatments that would not be possible in murine models, with resultant data that would be predictive of human tumor response
The current landscape of animal modeling for breast cancer is dominated by murine models, which have developed into powerful and multi-faceted tools for the BC researcher
Summary
Reviewed by: Thomas Liehr, Friedrich Schiller University Jena, Germany Ahmet Acar, Middle East Technical University, Turkey. In this mini review the status, advantages, and disadvantages of large animal modeling of breast cancer (BC) will be discussed. While most older studies of large animal BC models utilized canine and feline subjects, more recently there has been interest in development of porcine BC models, with some early promising results for modeling human disease. Used rodent models of BC were briefly reviewed to give context to the work on the large animal BC models. Availability of large animal BC models could provide additional tools for BC research, including availability of human-sized subjects and BC models with greater biologic relevance
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