Abstract
Abstract Background: This article describes the presentation, identification, and laparoscopic treatment of a large-cell neuroendocrine carcinoma arising from the endometrium. Case: A para 4, 43-year-old female was referred for treatment for menorrhagia. Clinical oncology, histopathology, and pathology departments of the hospital followed her presentation, diagnosis, and management. In addition, a literature review provided a comparison of treatment modalities in this type of tumor. Results: Ultrasound revealed a 40×32×38–mm heterogenous endometrial mass, representative of a fibroid, extending from the uterine fundus. Flexible hysteroscopy supported this diagnosis, showing a smooth, white submucosal mass, which was resected hysteroscopically. Initial histology suggested an anaplastic endometrial carcinoma. The tumor was strongly estrogen-receptor–positive and progestin-receptor–positive. Testing and treatment involved laparoscopic hysterectomy, bilateral salpingo-oophrectomy, pelvic-lymph node dissection ...
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