Abstract
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors that originate from interstitial cells of Cajal or their stem cell-like precursors. Generally, GISTs have specific c-KIT gene mutations. The incidence of GISTs is estimated to be 10 to 20 cases/one million individuals, and GISTs typically affect people over 50 years of age. The majority of GISTs are solitary. However, multifocal GISTs have been observed, especially in children. We report on two unusual adult cases of double GISTs that were treated by laparoscopic surgery. The first patient presented a polypoid mass of the fundus and a second isolated smaller tumor in the posterior wall of the lesser curvature of the stomach. A histopathological examination confirmed that both tumors were GISTs and were c-KIT-positive. A total laparoscopic gastrectomy was performed. In the second patient, GISTs were identified at the level of the fundus and the greater curvature of the stomach. A laparoscopic partial sleeve gastrectomy was performed. Both surgeries were successful with no complications or relapses at three to five years following surgery.
Highlights
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gastrointestinal tract that account for approximately 0.1% to 3% of all gastrointestinal malignancies [1]
GISTs originate from interstitial cells of Cajal, a complex cellular network that regulates gastrointestinal motility, or mesenchymal stem cells of the mesentery or omentum, which transform into the malignant phenotype that expresses the proto-oncogene c-Kit (CD 117) and less frequently the platelet-derived growth factor receptor-α (PDGFRA) [3,4]
GISTs vary from virtually benign diseases to aggressive tumors (20% to 30% of cases) with a five-year survival rate that ranges from 35% to 65% depending on the tumor size, the mitotic index and the tumor location [5]
Summary
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gastrointestinal tract that account for approximately 0.1% to 3% of all gastrointestinal malignancies [1]. Case report 1 A 59-year-old female patient with a history of hypertension, breast cancer and type II diabetes visited her general practitioner because of a stomachache, dysphagia to solids, weight loss (approximately 13 kg), and general fatigue that began three months earlier. She was referred to a gastroenterologist for further examinations. The histopathological and immunohistochemical examinations revealed two isolated GISTs (7 × 6 × 6 cm and 2.5 × 1 × 1 cm) that were c-kit- and CD34-positive and SMMA- and PDGFRA-negative. The immunohistochemical examinations were specific for double GISTs. The patient underwent laparoscopic resection by partial sleeve gastrectomy. After three years of follow-up, the patient is clinically and radiographically disease-free
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
