Laparoscopic pancreaticoduodenectomy: changing the management of ampullary neoplasms.

Abstract

The purpose of this study is to present the largest reported series comparing open pancreaticoduodenectomy (OPD) to total laparoscopic pancreaticoduodenectomy (TLPD) in patients with ampullary neoplasms. Patients undergoing OPD or TLPD for ampullary neoplasms from June 2012 to August 2016 were retrospectively identified. Perioperative outcomes were compared using a Wilcoxon rank-sum test, Student's t test, and Chi square analysis where appropriate. Kaplan-Meier estimates for progression-free survival (PFS) and overall survival (OS) were compared between the groups using the log-rank test. We identified 47 patients with ampullary neoplasms (adenocarcinoma n=36, neuroendocrine tumor n=7, undifferentiated n=1, adenoma n=3) undergoing OPD (n=25) and TLPD (n=22). The proportion of patients being offered TLPD has progressively increased every year over 5years: 0% (2012) to 50% (2015). There were no differences in baseline variables between the two groups. TLPD was associated with less blood loss (300 vs. 500mL, p<0.001) and shorter operative times (314 vs. 359min, p=0.024). No patient required conversion to an open procedure and there were no perioperative deaths in either group. TLPD was associated with lower rates of intra-abdominal abscess (0 vs. 16.0%, p=0.049), but there were no differences in rates of pancreatic fistula, bile leak, delayed gastric emptying, wound infection, length of stay, and readmission (all p>0.05). Among patients with adenocarcinoma, there was no difference in pathological features between the two groups (p>0.05) and all patients had negative margins. At a median follow up of 25months, there was no difference in PFS or OS between the two groups. TLPD in patients with ampullary neoplasms results in improved perioperative outcomes while having equivalent short and long-term oncologic outcomes compared to the traditional open approach.