Laparoscopic management of fallopian tube carcinoma with paraneoplastic cerebellar degeneration

Abstract

An asymptomatic tumor of the fallopian tube with elevation of serum CA125 concentration was found in a 75-year-old woman during a search for primary malignancy that was causing paraneoplastic cerebellar degeneration with a positive anti-Yo antibody. Since there were no apparent metastatic lesions detected by image diagnostic procedures, a diagnosis of early fallopian tube carcinoma was made preoperatively. After confirmation of the presence of a left tubal tumor without apparent invasion to the adjacent organs and peritoneal metastasis, laparoscopic salpingo-oophorectomy was subsequently performed. The histopathological diagnosis was of moderately differentiated serous adenocarcinoma of the fallopian tube with marked plasma cell infiltration. After surgery, the CA125 value immediately decreased, and there was no evidence of tumor recurrence noted thereafter. The patient died 51 months after surgery due to progression of neurological symptoms.