Laparoscopic liver resection as a safe and efficacious alternative to open resection for colorectal liver metastasis: a meta-analysis

Yanming Zhou,Hua Li,Lupeng Wu,Yaqing Xiao,Bin Li

doi:10.1186/1471-2482-13-44

Yanming Zhou, Hua Li + Show 3 more

Open Access

https://doi.org/10.1186/1471-2482-13-44

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Journal: BMC surgery	Publication Date: Oct 1, 2013
Citations: 60	License type: cc-by

Affiliation: First Affiliated Hospital of Xiamen University

Abstract

BackgroundThe safety and efficacy of laparoscopic liver resection (LLR) for colorectal liver metastasis (CLM) remain to be established. A meta-analysis was undertaken to compare LLR and open liver resection (OLR) for CLM with respect to surgical and oncologic outcomes.MethodsAn electronic search was performed to retrieve all relevant articles published in the English language by the end of March 2013. Data were analyzed using Review Manager version 5.0.ResultsA total of 8 nonrandomized controlled studies with 695 subjects were analyzsed. Intra-operative blood loss, the proportion of patients requiring blood transfusion, morbidity and the length of hospital stay were all significantly reduced after LLR. Postoperative recurrence, 5-year overall and disease-free survivals were comparable between two groups.ConclusionsLLR for CLM is safe and efficacious. It improves surgical outcomes and uncompromises oncologic outcomes as compared with OLR.

Highlights

The safety and efficacy of laparoscopic liver resection (LLR) for colorectal liver metastasis (CLM) remain to be established
The 8 studies included a total of 695 patients: 268 in LLR group and 427 in open liver resection (OLR) group
Two studies were conducted in the United States [13,15], one in Norway [9], Figure 1 Selection flow diagram

Summary

Introduction

The safety and efficacy of laparoscopic liver resection (LLR) for colorectal liver metastasis (CLM) remain to be established. A meta-analysis was undertaken to compare LLR and open liver resection (OLR) for CLM with respect to surgical and oncologic outcomes. Conclusions: LLR for CLM is safe and efficacious. It improves surgical outcomes and uncompromises oncologic outcomes as compared with OLR. 50% CRC patients developed liver metastasis during disease evolution, which is a major cause of cancer death [1]. Conventional open liver resection (OLR) is an effective treatment for colorectal liver metastasis (CLM), offering a 5-year survival of 16-74% and a 10-year survival of 9-69% [2].

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