Laparoscopic Frey Procedure - Multicenter Prospective Randomized Trial

Abstract

Indication: To compare the efficiency, advantages and selection criteria of laparoscopic Frey procedure. Materials and methods: The primary point of the trial: the frequency of complications in the early postoperative period after laparoscopic and open procedure (Clavien-Dindo classification (from grade II and above). From October 2018 to December 2019 Frey procedure were performed in 18 patients with chronic pancreatitis type C (classification of M.Buchler). All patients were divided for 2 group: I group - laparoscopic approach (n-9), II group - open approach (n-9). The age of the patients was 42 (25-69) years in I group and 44 (36-52) years in II group (p 0,8). The median size of the pancreatic head was 30 (23-38) mm in I group and 42 (31-73) mm in II group (p 0.6), the median diameter of the main pancreatic duct was 7 (4-10) mm and 8 (4-10) mm (p 0.16), respectively. Results: All operations in I group were performed laparoscopic. The operating time was 375 (320-501) minutes in I group and 240 (179-280) minutes in II group (p 0,08). Blood loss was 70 (30-200) and 100 (50-450) ml (p 0.5), respectively. The postoperative stay period was 4 (4-8) days in I group and 7 (5-14) days in II group (p 0.45). There was 1 (11.15%) complications in II group. The follow-up was 4 (3-8) months in I group and 4 (3-7) months in II group. Pain relief was complete in all groups. Conclusions: A prospective randomized trial demonstrates advantages of laparoscopic Frey procedure.