Abstract

Obesity is a chronic relapsing disease associated with comorbidity, disability, psychosocial impairment, and reduced life expectancy.1 In most developed and developing countries, the prevalence of obesity and related diseases such as type 2 diabetes mellitus continues to rise. Today, about one third of US adults are obese, and although the prevalence has doubled over recent decades, the prevalence of the more severe forms of obesity has increased 5- to 10-fold.2 The determinants of the current epidemic are complex and very difficult to address at a population level. The World Health Organization recognizes obesity as a societal issue related to fundamental changes in behavior associated with industrialization, urbanization, and loss of traditional lifestyles.3 Genes and gene-environmental interaction are also critical. The explosion of interest in preconception, fetal, and early life nutrition has highlighted the potential importance of epigenetic and metabolic programming in setting the scene for an individual's weight trajectory. Certainly, a weight problem during adolescence heralds a very high risk of a lifelong battle with weight.4 Obesity may more broadly be seen as a marker for, but not a necessary element of, the chronic disease driven by fundamental industrial and postindustrial changes in the environment and human behavior. Obesity prevention will be challenging and will require a multidimensional environmental and societal makeover.5 Unfortunately, as physicians and healthcare providers, our role in primary prevention will be limited. Although primary prevention should be a global priority, we must also focus on effective therapy for those affected by obesity and its associated diseases. However, the chronic nature of obesity is often forgotten and displaced by a quick fix or quick cure mentality, which is just as illogical as short-term approaches to other chronic conditions such as type 2 diabetes mellitus, dyslipidemia, hypertension, or coronary artery disease. Weight management …

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