Abstract
The naturally occurring analogs of neurotensin-(8-13), xenopsin, [Lys 8, Asn 9]neurotensin-(8-13) (LANT-6) and neuromedin N stimulated the production of intracellular cyclic GMP in murine neuroblastoma clone N1E-115, an adrenergic neuronal cell type. The order of potency was neurotensin-(8-13)>neurotensin>xenopsin>neuromedin N>LANT-6. Furthermore, xenopsin, LANT-6 and neuromedin N each inhibited the specific binding of [ 3H]neurotensin to intact N1E-115 cells in a dose-related fashion. The order of affinity of the peptides for the neurotensin receptor was neurotensin-(8-13)>xenopsin>neurotensin N>LANT-6.
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