Abstract
Objective: This research aims to evaluate the antibacterial activity and determine the chemical composition of the aqueous extract of the bark of Lannea barteri Engl. (DA) used in the traditional treatment of urinary tract infections in the Ivory Coast.Methods: The material is composed of DA, the bacterial strains of Pseudomonas aeruginosa and Acinetobacter baumannii, isolated from the urine of patients from different hospitals and subsequently stored. The qualitative analysis was performed using color-based detection tests and thin layer chromatography (TLC) reactions and the quantification of total phenols, flavonoids, flavone aglycones and anthocyanins using the method of Folin Ciocalteu. The method of diffusion on Mueller Hinton (MH) agar medium has been used for sensitivity tests. Results: The phytochemical screening of DA has revealed the presence of polyphenols, terpenes, and derivatives, coumarins, tannins, flavonoids, and alkaloids. Furthermore, the quantification of some polyphenols such as flavonoids, flavone aglycones, and anthocyanins was determined. The total polyphenols found was 0.757±0.003 mg/g MS representing respectively; 0.230±0.01 for flavonoids; 0.028±0.02 for flavone aglycones and 0.016±0.02 mg/g MS for anthocyanins. DA is bactericidal against Pseudomonas aeruginosa and Acinetobacter baumannii, which are mainly responsible for urinary tract infections.Conclusion: The bark of Lannea barteri Engl. (DA) is rich in flavonoids, flavone aglycones, and anthocyanins which are probably responsible for its antibacterial properties on Pseudomonas aeruginosa and Acinetobacter baumannii. This research thereby supports the use of this plant in the treatment of urinary tract infections.
Highlights
Nosocomial infections are currently a major public health problem in some developing countries
Chemical study Qualitative analysis With an extractive value of 7.75 %, the study of the chemical composition of the aqueous extract of Lannea barteri Engl. bark (DA) performing the detection tests by color reactions indicated the presence of several secondary metabolites
We count polyphenols, flavonoids, tannins, coumarins, alkaloids, terpenes, and derivatives. The presence of these phyto-compounds was confirmed by thin layer chromatography (TLC)
Summary
Nosocomial infections are currently a major public health problem in some developing countries. In Ivory Coast, the prevalence is estimated at about 12% [1] These infections are partly due to hygienic conditions in the hospitals. This situation promotes the proliferation of different kinds of bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Because of their high resistance to antibiotics, these bacteria are mostly responsible for the transmission of many hospital pathologies including urinary tract infections [2,3,4,5,6]. This multidrug-resistant antibiotic limits all possible therapeutic choices, leading to an increase in the morbidity and mortality rate [2]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmacy and Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
