Abstract
The studies of model biological membranes consisted of phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were carried out by means of the Langmuir monolayer technique using subphases containing chitosan (Ch), titanium (IV) oxide (TiO2), hyaluronic acid (HA) or mixture of them. The aim was to determine the effect of individual components of subphase and their respective combinations on behavior of the DPPC membrane. The systems were tested at room temperature (20 °C) and at a natural pH of about 4.8, which was close to the pH of the human skin (4.7–5.6). The surface pressure–area per molecule (π–A) isotherms were obtained. Their analysis showed that all substances studied affected the phospholipid membrane which was revealed in the changes of mean molecular area, compression modulus and pressure of the liquid-expanded/liquid-condensed (LE/LC) phase transition. The results were discussed in terms of the nature and strength of mutual interactions. The more profound effect was found at low surface pressures at which the monolayers occurred in more expanded state. However, at the surface pressure corresponding to that of biological membranes, systems had very similar parameters compared to model DPPC isotherm.
Highlights
Chitosan (Ch) is a biopolymer that has recently enjoyed a lot of popularity
Compression isotherms are characterized by particular regions that depict the state of the DPPC monolayer: gas (G), decompressed liquid (LE), liquid state (LE)–LC phase transition, and condensed LC
Further compression leads to a phase transition from decompressed liquid state (LE) to condensed liquid (LC)
Summary
Chitosan (Ch) is a biopolymer that has recently enjoyed a lot of popularity. This is due to a number of its interesting properties, resulting from its structure. Due to its bioactivity and biodegradability Ch is popular among pharmaceutical, medical and cosmetic concerns. It is used primarily as a support for the supply of drugs and proteins (Moradi et al 2019), biosensors (Zhang et al 2018), nanofibers (scaffolds in tissue engineering) (Rijal et al 2018; Bhowmick et al 2018). In the area of life science, titanium dioxide (TiO2) is often found, which is generally associated with its role as
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