Abstract
Langerhans cells (LC) are dendritic non-epithelial cells which form a network within stratified squamous epithelium. These cells are of stem cell origin and are important antigen gathering and presenting cells. In oral epithelium LCs increase in number as dental plaque accumulates (Walsh et al. 1985). The anti-convulsant drug Epanutin predisposes to gingival hyperplasia in patients with poor oral hygiene (Klar, 1973). The mechanism by which gingival overgrowth is initiated is not fully understood although there may be changes in the host response to plaque antigens and thus in the mucosal LC numbers. The present study compares the numbers of LCs in two forms of gingival inflammation, epanutin induced hyperplasia and chronic gingivitis, both before and after corrective therapy.
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