Abstract
Langerhans cell sarcoma is a rare, high-grade malignant neoplasm of the Langerhans cells, characterised by overtly malignant cytologic features, multiorgan involvement and an aggressive clinical course with a poor prognosis. It is generally considered to be a malignant variant of histiocytosis that can develop de novo or from antecedent Langerhans cell histiocytosis. Transdifferentiation of non-Langerhans cell lymphoid neoplasms to Langerhans cell neoplasms is not well documented. We report a case of Langerhans cell sarcoma in a 66-year-old male with a history of a stage IIIa follicular lymphoma who presented with multiple lesions in the liver and lung.
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