Abstract
Purpose To report a case of Langerhans cell histiocytosis presenting as a limbal nodule. Design Observational case report. Method A 26-year-old man presented with a superior limbal mass. On clinical examination, an infiltrative/neoplastic lesion was suspected, and a differential diagnosis of limbal amyloidosis, limbal fibrous histiocytoma, lymphoma, and juvenile xanthogranuloma was made. There was no other associated ocular or systemic abnormality. An excision biopsy was performed. Results The histopathology and immunohistochemical staining examination established the diagnosis of limbal Langerhans cell histiocytosis. Conclusion To the best of our knowledge, this is an unusual presentation of Langerhans cell histiocytosis, and although rare, Langerhans cell histiocytosis should be included in the differential diagnosis of a limbal mass.
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