Abstract
Lamin B1 (LMNB1) is a type V intermediate filament protein and is one of the major components of the nuclear lamina, a filamentous meshwork underlying the inner nuclear membrane of Eukaryotic cells. LB1 forms a stable structure in the nuclear lamina and nucleoplasm and, together with other lamins (e.g., lamin A/C), contributes to determine nuclear structure and function. Recently, Padiath and colleagues found that duplication of the gene encoding LMNB1 protein is associated with the development of adult-onset autosomal dominant leukodystrophy (ADLD).
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