Abstract
Laminin has recently been reported to inhibit both A β40 and A β42 fibril formation in vitro. Laminin was thus suggested to be an effective therapeutic agent for Alzheimer's disease. However, some recent reports have shown that A β fibril formation may not necessarily be linked to the development of A β neutotoxicity. In the present study, we thus investigated whether or not laminin affects A β40 and A β42-induced neurotoxicity. The findings of the present study by using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) dye reduction test showed laminin not to have an inhibitory effect on A β40 or A β42-induced cytotoxicity in PC12 cells while A β fibril formation was inhibited under the conditions used in the present study. The findings of the present study therefore do not support the hypothesis that A β fibril formation is absolutely required for the development of A β cytotoxicity.
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