Abstract
Conclusion. This study confirms the wide range of vascular architecture in juvenile angiofibromas. Proof of laminin α2 expression in tumour vessels is suggested to indicate presence of vessels of early developmental stage in juvenile angiofibromas, supporting the concept that plexus remnants of the first branchial arch artery contribute to the vascular tumour component. Objectives. Laminins, one of the major components of vascular wall basement membranes, have been implicated in tumour growth and have been shown to have developmentally regulated expression patterns. The goal of this study was to analyse the expression of laminins in juvenile angiofibromas. Materials and methods. A detailed analysis of the laminin isoform expression was performed by immunofluorescence staining for laminin chains α1, α2, α3, α4, α5, β1, β2, β3, γ1, γ2, and γ3 on cryosections of 10 juvenile angiofibromas and inferior nasal turbinate tissue for control. Results. Vascular staining of the different laminin chains revealed areas of differential vessel density in juvenile angiofibromas and irregularities in vessel size, configuration and architecture. Similar to vessels in nasal turbinates, laminins α4, α5, β1, β2 and γ1 were found to be expressed in juvenile angiofibroma vessels. In contrast to vessels of nasal turbinates, staining for α2 and α3 chains was only detected in vessels of juvenile angiofibromas.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.