Abstract
Longevity-assurance gene 1 ( LAG1) is a yeast longevity gene. Homologues of the Lag1 protein can be found throughout phylogeny, although sequence similarity is very limited. The Lag1 protein is located in the endoplasmic reticulum (ER), where it helps to accelerate the transport of glycosylphosphatidylinositol (GPI)-anchored proteins to the Golgi. This function of Lag1p results from its participation in ceramide synthesis. Thus, Lag1p and its homologues are likely to play a role in ceramide signaling, which affects growth, proliferation, stress resistance, and apoptosis. This provides a wide range of physiologic processes through which Lag1p may impinge upon life span.
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