Abstract
Herein we report the creation of nanocomplexes on the base of scintillation nanoparticles (SNPs) LaF3:Tb3+ and organic photosensitizer Rose Bengal (RB) with an efficient electronic excitation energy transfer upon both UV-light and X-ray irradiation. In such LaF3:Tb3+ − RB complexes, SNPs act as an energy transducer absorbing high-energy photons and transferring them to the organic RB photosensitizer with subsequent singlet oxygen 1O2 generation for X-ray activated photodynamic therapy (PDT). For the first time, it has been shown that under X-ray irradiation LaF3:Tb3+ SNPs produce hydroxyl radicals ·OH via X-ray induced holes interactions with water molecules adsorbed at the surface of SNPs. Such extra-bonus of LaF3:Tb3+ SNPs can solve the problem of low efficiency of conventional PDT in hypoxic areas of the tumor, which suffer from the lack of oxygen molecules.
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