Abstract
Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that substantially impacts a person’s quality of life. Recent studies to improve muscle function through the intake of various functional food materials are attracting attention. However, it is not yet known whether probiotics can improve muscle mass and muscle strength and affect physical performance. Lactobacillus plantarum HY7715 (HY7715) is a lactic acid bacteria isolated from kimchi. The present research shows that L. plantarum HY7715 increases physical performance and skeletal muscle mass in 80-week-old aged Balb/c male mice. HY7715 not only induces myoblast differentiation and mitochondrial biogenesis but also inhibits the sarcopenic process in skeletal muscle. In addition, HY7715 recovers the microbiome composition and beta-diversity shift. Therefore, HY7715 has promise as a functional probiotic supplement to improve the degeneration of muscle function that is associated with aging.
Highlights
Skeletal muscle is one of the largest organ in the body, accounting for about 40–50% of the body mass [1,2]
The effects of orally ingested microorganisms on health and the prevention of disorders have been studied for a long time, and the correlation between microbiota, health conditions, and disease development is an area of active research [36]
Probiotics are live microorganisms that provide health benefits for the host when administrated in adequate amounts
Summary
Skeletal muscle is one of the largest organ in the body, accounting for about 40–50% of the body mass [1,2]. The preservation of skeletal muscle function is important to maintain whole-body energy homeostasis and the capacity to perform activities associated with daily living. There is an age-induced loss in skeletal muscle mass and function, known as sarcopenia. Sarcopenia is associated with biological, structural, molecular, and functional changes in skeletal muscle. These changes lead to decreased mobility and increased susceptibility to falls, various diseases, and mortality [7,8]. Recent in vitro and in vivo studies suggest that modulating the molecular and cellular changes that occur during skeletal muscle aging is a promising antisarcopenia strategy [10,11,12]
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