Abstract
(1) Background: An age-related cognitive decline is commonly affecting the life of elderly with symptoms involved in progressive impairments to memory and learning. It has been proposed that probiotics could modulate age-related neurological disorders via the gut–brain axis. (2) Methods: To investigate the anti-aging effect of probiotic Lactobacillus plantarum GKM3, both survival tests and cognitive experiments were conducted in the SAMP8 mice model. The six-month-old SAMP8 (n = 20 in each gender) were fed with probiotic GKM3 at a dosage of 5.1 × 109 and 1.0 × 109 cfu/ kg B.W./day until their natural death. Then, the life span was investigated. Three-month-old SAMP8 (n = 10 in each gender) were administered GKM3 for 14 weeks. Then, the behavior tests and oxidation parameters were recorded. (3) Results: GKM3 groups showed significantly increased latency in the passive avoidance test and time of successful avoidance in the active avoidance test. The TBARS and 8-OHdG from mice brains also showed a significant reduction in the groups treated with GKM3. In addition, lower accumulation of the amyloid-β protein was found in SAMP8 mice brains with the supplement of GKM3. (4) Conclusions: These results indicated that L. plantarum GKM3 delayed the process of aging, alleviated age-related cognitive impairment, and reduced oxidative stress.
Highlights
It has been an issue that population-suffered cognitive impairment has become bigger following the growth of the amount of older individuals in the last decade [1]
Similar to the observation in female senescence-accelerated prone mice P8 (SAMP8) mice, 12.00 months and 15.50 months with a 50% survival rate was showed in groups fed probiotic GKM3 at a dosage of 1.0 × 109 CFU/kg BW/day and 5.1 × 109 CFU/kg BW/day, respectively; 10.50 months with a 50% survival rate was observed in the female control group (Figure 1B)
The female SAMP8 mice presented shorter life expectancies than males as the basis in this experiment; interestedly, the effect of L. plantarum GKM3 in terms of the lifespan had a greater impact on females
Summary
It has been an issue that population-suffered cognitive impairment has become bigger following the growth of the amount of older individuals in the last decade [1]. Ginseng (Panax quinquefolius) root extract demonstrated improved cognitive function and was marked as a favorite by the Koreans [8]. Children who consumed plant-based enteral nutrition showed higher SCFAs than the normal kids in their stool samples [16]. These SCFAs can play an important role in the human gastrointestinal epithelium [17]. Butyrate has been studied regarding the effect of suppressing colonic inflammation in the human gut [19] It matters what kind of microbiota or specific bacteria is in the human gut, especially in terms of influencing body health and longevity [20,21]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
