Abstract
It has been reported that certain LAB isolated from fermented foods are effective suppressors of allergic symptoms. In the present study, the immunomodulatory effects of Lactobacillus pentosus KF340 (LPKF340), originally derived from a traditional fermented Korean food made mainly of cabbage or radish, were tested in a mouse model of allergic atopic dermatitis (AD). Prior treatment with LPKF340 could effectively alleviated pathologic AD symptoms induced by dust mite extract, including oedema and erythema, and decreased lymphocyte infiltration into the inflamed region. In the LPKF340-fed group, the level of allergic cytokine, IL-4, was reduced, while that of anti-inflammatory IL-10 was increased. It was found that splenic regulatory B10 cells were stimulated to produce IL-10 by dendritic cells (DCs) of Peyer's patch. This was dependent on the activity of B cell activating factor in DCs. Taken together, these results suggest that LPKF340 might act as an orally active immunomodulator for allergic AD.
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