Abstract
Lactobacillus pentosus has the beneficial function of regulating the host’s immune system and plays an indispensable role in intestinal health. The purpose of this study was to investigate the specific mechanism by which L. pentosus relieves dextran sulfate sodium (DSS) induced ulcerative colon inflammation. We randomly divided 24 mice into three groups, which were administered either a basic diet, drinking water with 2.5% DSS (DSS), or drinking water with 2.5% DSS and intragastric administration of L. pentosus (DSS + L. pentosus). DSS was added to the drinking water on days 8 to 12, and L. pentosus was administered on days 12 to 19. Serum was collected for metabolomic analysis, colon length and weight were measured, and colon contents were collected to detect microbial structural composition. Compared with the DSS group, the DSS + L. pentosus group had significantly higher levels of indolepyruvate and pantothenic acid in the serum and significantly lower levels of 3,4-dimethyl-5-pentyl-2-furannonanoic acid and 5-oxo-6-trans-leukotriene B4. Moreover, compared with the other two groups, the DSS + L. pentosus group had a significantly greater abundance of Akkermansia. The abundance of Akkermansia was positively correlated with indolepyruvate and pantothenic acid levels. Therefore, L. pentosus can interact with Akkermansia to increase its abundance in the intestinal tract. This results in the production of metabolites that are beneficial for the regulation of intestinal immunity, thereby alleviating DSS-induced ulcerative colon inflammation.
Highlights
Inflammatory bowel disease (IBD) is a chronic disease caused by the interaction of environmental, immune, genetic, and other factors (Batura and Muise, 2018)
The results demonstrated that the body weight of dextran sulfate sodium (DSS) group was reduced in comparison with CON group (Figure 1B, p < 0.05), there is no difference in colon length, but the weight of colon was decreased in DSS group in relative with CON and DSS-L. pentosus group (Figure 1D, p < 0.05)
We developed a histological scoring system (Table 1), which was used to show that histological injury was significantly greater in the DSS group than the CON and DSS-L. pentosus groups (Figure 2D)
Summary
Inflammatory bowel disease (IBD) is a chronic disease caused by the interaction of environmental, immune, genetic, and other factors (Batura and Muise, 2018). Lactobacillus pentosus Alleviates Colitis and rectum, usually accompanied by inflammatory lesions of the colonic mucosa and submucosa (Danese and Fiocchi, 2011) In severe cases, it can cause diarrhea or even blood in the stool, and the occurrence of repeated illnesses eventually increases the risk of developing cancer (Ungaro et al, 2017). The specific cause of recurrent ulcerative colitis is not yet clear (Kaplan, 2015), approximately 200 genetic risk loci have been proposed for IBD. These susceptibility genes include those involved in autophagic regulation and microbial sensors that activate autophagy (Matsuoka and Kanai, 2015). We believe that remodeling the healthy gut microbial community structure will be an effective treatment strategy for colonic inflammation
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