Abstract
Sarcopenia is a common impairment in the elderly population responsible for poor outcomes later in life, which is enhanced by inflammation. Only a few strategies have been reported to reduce sarcopenia. We investigated whether Lactobacillus paracasei PS23 (LPPS23) decelerates age‐related muscle loss and its inflammatory response; LPPS23 has been reported to delay some age‐related disorders. Female senescence‐accelerated mouse prone 8 (SAMP8) mice were divided into three groups (n = 6 each): non‐aging (16‐week‐old), control (28‐week‐old), and PS23 (28‐week‐old) groups. The control and PS23 groups were given saline and LPPS23, respectively. We evaluated the effects of LPPS23 by analyzing body weight and composition, reactive oxygen species, and IL‐6. The positive anti‐ROS effect of LPPS23 in the aged SAMP8 mice demonstrated that LPPS23 may protect muscle mitochondria against ROS damage, which may be associated with a lower level of sarcopenia in aged SAMP8 mice. Similar to LPPS23, some probiotics has been reported to have anti‐ROS properties; more probiotics may be also proofed to use for modulating sarcopenia in the future.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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