Abstract
A defective intestinal epithelial tight junction (TJ) barrier has been postulated to be a key pathogenic factor in allergic disorders, including food allergy. Enhancement of the TJ barrier might be a target for prevention or treatment of such diseases. Our lab recently showed that Lactobacillus acidophilus (LA) caused an enhancement of the intestinal TJ barrier that was mediated by attachment of live LA to toll-like receptor-2 (TLR2) on the apical membrane surface of enterocytes. The aim of this study was to delineate TLR2 signaling mechanisms mediating the LA-induced enhancement of the intestinal TJ barrier.
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