Abstract
Using cellulose ion exchangers and starch gel electrophoresis, four components of LDH have been found in the cerebral cortex of mouse and guinea pig. The several components tested could also be distinguished by their ratios of rates of reduction of DPN and two of its analogs. These components apparently each contribute to a different degree to the increase in LDH activity of the cortex which occurs during development. Maturation of the liver is accompanied by a reduction in the number of components of LDH in both mouse and guinea pig. With the liver of the mouse, peaks of LDH activity in the chromatograms which corresponded in their position with those from cerebral cortex also gave the same ratios of reduction of DPN and its analogs.
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