Abstract
Keeping in view the potential of biodegradable polymers for different biomedical applications, in the present study, an attempt has been made to synthesize the poly(lactic acid), poly(glycolic acid) and poly(lactic-co-glycolic acid) based polymer matrices and thereafter use in drug delivery devices. The polymers and copolymers thus prepared were characterized by SEMs, FTIR, swelling studies (as a function of time, pH, temperature and [NaCl]), hydrolytic and biocompatibility studies. The Non-Fickian diffusion mechanism has been observed for the release of a model drug (famotidine) from these polymer matrices. It has been observed that hydrolytic degradation of polymeric matrix is strongly influenced by the pH of the medium and nature of the polymer matrix.
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