Abstract
The effect of lactic acidosis on renal blood flow and glomerular nitration rate was studied in sheep. Renal blood flow was significantly reduced with blood lactic acid concentrations of 17.7 mM./L. or greater and a blood pH of 7.30 or less. The magnitude of reduction in glomerular nitration rate was not proportional to those observed in renal blood flow. Significant reductions in glomerular nitration rate were observed with blood lactic acid concentrations of 30.6 mM./L. or greater and a blood pH of 6.89 or lower. Tubular reabsorptive transport maximum for lactic acid was calculated to be 66.4 mg. per minute.
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