Abstract
Lactic acid bacteria: a promising alternative for recombinant protein production
Highlights
Even though the use of Lactic Acid Bacteria (LAB) is well documented for a variety of dairy food fermentation dating back to the earliest written records [1,2], the use of these Gram-positive anaerobic microorganisms as recombinant microbial cell factories has taken place during the last decades
Several studies are being performed concerning B. subtilis quality control system, an approach that will significantly improve the successful production of difficult-to-express proteins in Gram-positive microorganisms in a near future [12,20]
Recombinant protein production in LAB is far from being an extensively explored field, being much of their possibilities still to come to the surface, there are already examples in the literature showing the great potential of this safe expression system
Summary
Even though the use of Lactic Acid Bacteria (LAB) is well documented for a variety of dairy food fermentation dating back to the earliest written records [1,2], the use of these Gram-positive anaerobic microorganisms as recombinant microbial cell factories has taken place during the last decades. Considering the limitations imposed by the use of E. coli, in the last years an increasing number of scientists are considering Grampositive bacteria as a much optimal and safer microbial alternative for recombinant protein production.
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