Abstract
Because of the reduced affinity of haemoglobin S to oxygen and the altered blood rheological profile of sickle cell trait carriers (AS), it is often thought that exercise physiological responses should differ between AS and subjects with normal haemoglobin (AA). The present study aimed to compare the ability to remove blood lactate and the characteristics of oxygen uptake (VO2 kinetics were not significantly different between the two groups (P > 0.05). No significant relationship was observed between 2 and A2 (r = 0.04; P > 0.05) or between 2 and 2 (r = -0.44; P > 0.05) in all groups. It seems that the ability to recover or to remove lactate after a short supramaximal exercise does appear unaltered by sickle cell trait. It is possible that the elevated blood viscosity reported several times in AS could have promoted greater vasodilatation which in turn may favour exercise recovery to a similar level observed in subjects with normal haemoglobin. Our findings may suggest that AS and AA subjects need similar recovery after exhausting exercise. However, it is also known that AS may be prone to medical complications in response to exercise. So, the presence of clinical sign should justify to prolong recovery or to stop exercise in AS.
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