Abstract
Lactate Fuels the Neonatal Brain
Highlights
To address this question, Ivanov et al (2011) simultaneously recorded oxygen tension, NAD(P)H fluorescence transients and local field potentials during electrical stimulation of the hippocampal Schaffer collateral pathway in neonatal brain tissue slices from mice
After ideal experimental conditions were established, hippocampal slices were first superfused with artificial cerebrospinal fluid (ACSF) containing 10 mM glucose and with modified ACSF containing 5 mM glucose and 5 mM l-lactate
Their reasoning was if glucose alone is sufficient to sustain enhanced network activity, the addition of lactate should not change tissue metabolic states and synaptic function
Summary
Their reasoning was if glucose alone is sufficient to sustain enhanced network activity, the addition of lactate should not change tissue metabolic states and synaptic function. The addition of lactate significantly increased oxygen consumption (+31%) and enhanced local field potentials (+41%) during the train stimulation (10 s, 10 Hz) and radically modified the biphasic NAD(P)H signaling: the early oxidation phase was strongly augmented while the overshoot was attenuated. The authors went on to investigate whether lactate (10 mM) can sustain synaptic function in the absence of glucose as has been reported for mature brain tissue (Schurr et al, 1988).
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